abstract：:This study was aimed to investigate the functional roles of cytokine receptor (CXCR) CXCR2 and CXCR7 in esophageal cancer (EC). Specific small interfering RNAs (siRNA) against CXCR2 and CXCR7 were transfected into EC cell lines TE-1, EC9706, and EC109 cells. Expression of CXCR2 and CXCR7 was validated, along with cell...

journal_title：American journal of translational research

authors： Wu K,Cui L,Yang Y,Zhao J,Zhu D,Liu D,Zhang C,Qi Y,Li X,Li W,Zhao S

更新日期：2016-08-15 00:00:00

abstract：:HNF1A-antisense 1 (HNF1A-AS1), a long non-coding RNA (lncRNA), is associated with metastasis and is an independent prognostic factor for lung cancer. Recent studies demonstrated that HNF1A-AS1 play important roles in cacinogenesis. However, the exact effects and molecular mechanisms of HNF1A-AS1 in osteosarcoma (OS) p...

journal_title：American journal of translational research

authors： Zhao H,Hou W,Tao J,Zhao Y,Wan G,Ma C,Xu H

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:The aim of this study was to explore the role of autophagy in the cold I/R injury following lung transplantation. METHODS:The rat orthotopic lung transplantation model was established to perform the level of autophagy in the cold I/R injury in this study. The pretreatment of inhibitor (3-Methyladenine [3-MA...

journal_title：American journal of translational research

authors： Liu S,Zhang J,Yu B,Huang L,Dai B,Liu J,Tang J

更新日期：2016-08-15 00:00:00

abstract：OBJECTIVE:Comparative study of type 2 diabetes and healthy controls by metabolomics methods to explore the pathogenesis of Type II diabetes. METHODS:Gas chromatography - mass spectrometry (GC-MS) with a variety of multivariate statistical analysis methods to the healthy control group 58 cases, 68 cases of Type II diab...

journal_title：American journal of translational research

authors： Zhang N,Geng F,Hu ZH,Liu B,Wang YQ,Liu JC,Qi YH,Li LJ

更新日期：2016-07-15 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) is a member of the Tec-family non-receptor tyrosine kinases family. It has previously been reported to be expressed in B cells and has an important role in B-cell malignancies. While the roles of Btk in the pathogenesis of certain B-cell malignancies are well established, the functions o...

journal_title：American journal of translational research

authors： Wang JD,Chen XY,Ji KW,Tao F

更新日期：2016-07-15 00:00:00

abstract：:Evidence has shown that gastrin-releasing peptide receptor (GRPR) is involved in responses to stress and anxiety. The primary role of GRPR is to stimulate corticotrophin-releasing hormone (CRH) or adrenocorticotropic hormone (ACTH) secretion. Thus, the mechanisms of GRPR signaling should be elucidated to discover nove...

journal_title：American journal of translational research

authors： Yao L,Chen J,Chen H,Xiang D,Yang C,Xiao L,Liu W,Wang H,Wang G,Zhu F,Liu Z

更新日期：2016-07-15 00:00:00

abstract：:Interleukin-21 (IL-21) and T helper 17 (Th17) cells are known to be involved in the pathogenesis of psoriasis, but little is known about their relationship in psoriasis. Herein, we investigated whether IL-21 could regulate Th17 cell induction in patients with psoriasis vulgaris. 32 patients with psoriasis vulgaris and...

journal_title：American journal of translational research

authors： Wang Y,Wang LL,Yang HY,Wang FF,Zhang XX,Bai YP

更新日期：2016-07-15 00:00:00

abstract：:In Xinjiang, China, esophageal carcinoma has a high incidence in Kazak and Uighur populations. MicroRNA (miR)-21 and miR-375 are related to esophageal carcinoma. This study thus investigated their potencials in early diagnosis and prognosis in Kazak and Uighur populations, to provide evidences for serum markers of eso...

journal_title：American journal of translational research

authors： Lv H,He Z,Wang H,Du T,Pang Z

更新日期：2016-07-15 00:00:00

abstract：UNLABELLED:Liver transplantation is an effective approach to end-stage liver disease. Shortage of donor liver and increased waiting time for liver transplantation necessitate the development of an organ culture system by which livers can be cultured and maintained ex situ for a prolonged period of time. The aim of this...

journal_title：American journal of translational research

authors： Dong J,Xia L,Shen H,Bian C,Bao S,Zhang M,Du Y,Dai Y,Zhao L,Xu Y,Xiong Q,Xu J,Xu L

更新日期：2016-06-15 00:00:00

abstract：:The skin serves as a physical and chemical barrier to provide an initial line of defense against environmental threats; however, this function is impaired in diabetes. Vγ4 γ δ T cells in the dermis are an important part of the resident cutaneous immunosurveillance program, but these cells have yet to be explored in th...

journal_title：American journal of translational research

authors： Liu Z,Xu Y,Zhang X,Liang G,Chen L,Xie J,Tang J,Zhao J,Shu B,Qi S,Chen J,Luo G,Wu J,He W,Liu X

更新日期：2016-06-15 00:00:00

abstract：:Fibrous sheath CABYR binding protein (FSCB) is regulated by protein kinase A (PKA)-mediated tyrosine phosphorylation in the spermatozoa capacitation. Recently, we showed that FSCB phosphorylation activated spermatozoa motility. Nevertheless, the underlying mechanisms have not been completely elucidated. Here, we showe...

journal_title：American journal of translational research

authors： Zhang X,Chen M,Yu R,Liu B,Tian Z,Liu S

更新日期：2016-06-15 00:00:00

abstract：:Angiopoietin-1 (Ang-1) plays a critical role in the regulation of endothelial cell survival and vascular maturation and stability. However, its role in hematopoiesis is not clear. Here, we determined effect of Ang-1 on the recovery of hematopoiesis in radiated mice. By injecting an Ang-1 plasmid, we found that Ang-1 w...

journal_title：American journal of translational research

authors： Sun L,Zhang H,Bi L,Shi YF,Xing C,Tang L,Jiang S,Yu K

更新日期：2016-05-15 00:00:00

abstract：:The important roles of miR-124 in the development and progression of various diseases are being increasing recognized. This study was aimed to investigate the potential roles of miR-124 in dopaminergic (DA) neuronal apoptosis and autophagy in Parkinson's disease (PD) and to explore their mechanisms. Human SH-SY5Y cell...

journal_title：American journal of translational research

authors： Gong X,Wang H,Ye Y,Shu Y,Deng Y,He X,Lu G,Zhang S

更新日期：2016-05-15 00:00:00

abstract：BACKGROUNDS:The deubiquitinating enzyme OTUB1 participates in multiple cellular processes. However, its expression and functions in gastric adenocarcinoma remains unknown. The aim of this study was to investigate the expression of OTUB1 and its biological role in gastric adenocarcinoma. METHODS:We used immunohistochem...

journal_title：American journal of translational research

authors： Weng W,Zhang Q,Xu M,Wu Y,Zhang M,Shen C,Chen X,Wang Y,Sheng W

更新日期：2016-05-15 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) has similar clinical pathological changes to alcoholic hepatitis. It shows increased incidence and young trend year by year. Polyene phosphatidyl choline (PPC) is widely used in clinic for liver disease treatment. The effect and mechanism of PPC on NASH have not been fully elucidate...

journal_title：American journal of translational research

authors： Cao M,Li X,Zhang B,Han S,Yang Y,Zhou B,Zhang Y

更新日期：2016-05-15 00:00:00

abstract：:Aspergillus is widely distributed in the Earth's biosphere. It has strong adaptive capacity, and lives as saprophytic or parasitic life. This study aims to investigate the role of E-cadherin for adhesion of Aspergillus fumigatus blastospores in a human epithelial cell line (A549) and search the correlated molecule in ...

journal_title：American journal of translational research

authors： Xu XY,Chen F,Sun H,Chen C,Zhao BL

更新日期：2016-05-15 00:00:00

abstract：:Rcinoma-associated fibroblasts (CAFs) are a major constituent of the tumor microenvironment. Cancer cells can induce the transformation from normal fibroblasts (NFs) into CAFs, reciprocally, CAFs promote tumor invasion and proliferation. TGF-β has been the mostly accepted factor to fuel NFs transformation into CAFs. G...

journal_title：American journal of translational research

authors： Zheng L,Xu C,Guan Z,Su X,Xu Z,Cao J,Teng L

更新日期：2016-04-15 00:00:00

abstract：:As an autoimmune disease, myasthenia gravis is caused by the dysfunction of neural transmission. Acetylcholine is known to exert its function after entering into synaptic cleft through binding onto postsynaptic membrane. The role of acetylcholine in binding MuSK in myasthenia gravis, however, remains unknown. A total ...

journal_title：American journal of translational research

authors： Chen R,Chen S,Liao J,Chen X,Xu X

更新日期：2016-04-15 00:00:00

abstract：:This study aims to investigate the role of endocytoplasmic reticulum (ER) stress induced by spinal cord injury (SCI) in blood-spinal cord barrier (BSCB) disruption and the effect of phenylbutyrate (PBA) on BSCB disruption after SCI. After a moderate contusion injury at the T9 level of spinal cord with a vascular clip,...

journal_title：American journal of translational research

authors： Zhou Y,Ye L,Zheng B,Zhu S,Shi H,Zhang H,Wang Z,Wei X,Chen D,Li X,Xu H,Xiao J

更新日期：2016-04-15 00:00:00

abstract：:Interleukin-1β (IL-1β) plays an important role in brain injury after focal ischemia, and bone marrow-derived mesenchymal stem cells (BMSCs) are capable of reducing the expression of IL-1β, we investigated the effects of BMSCs transplantation on brain edema and cerebral infarction as well as the underlying mechanisms v...

journal_title：American journal of translational research

authors： Zhao Y,Wang X,Dong P,Xu Q,Ma Z,Mu Q,Sun X,Jiang Z,Wang X

更新日期：2016-03-15 00:00:00

abstract：:Isoflurane (ISO) exhibits neuroprotective effects against inflammation and apoptosis. However, the role of ISO in motoneuronal apoptosis induced by activated microglia remains poorly studied. We investigated the protective effects of ISO on the apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons induced by lipop...

journal_title：American journal of translational research

authors： Yang S,Liu J,Zhang X,Tian J,Zuo Z,Liu J,Yue X

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Systemic maternal inflammation and neonatal hyperoxia arrest alveolarization in neonates. The aims were to test whether human mesenchymal stem cells (MSCs) reduce lung inflammation and improve lung development in perinatal inflammation- and hyperoxia-induced experimental bronchopulmonary dysplasia. METHODS:...

journal_title：American journal of translational research

authors： Chou HC,Li YT,Chen CM

更新日期：2016-02-15 00:00:00

abstract：:Anthracycline-based chemotherapy is a conventional treatment for breast cancer. However, it can negatively affect host immune function and thereby impair patients' quality of life. Boosting the host immune system and reducing the adverse effect of chemotherapy are important for effective cancer treatment. Natural kill...

journal_title：American journal of translational research

authors： Feng H,Dong Y,Wu J,Qiao Y,Zhu G,Jin H,Cui J,Li W,Liu YJ,Chen J,Song Y

更新日期：2016-02-15 00:00:00

abstract：:Both POEMS syndrome and IgG4 related diseases are uncommon and clinical manifestations have been multifarious and nonspecific. There is still no literature describing the relationships between these two diseases. This study describes a case of a 33-year-old woman with POEMS syndrome, who had high serum IgG4 concentrat...

journal_title：American journal of translational research

authors： Zheng M,Zhou P,Zheng K,Meng L,Liu X,Chu M,Lu J,Dong L

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Emerging evidence indicated that dysregulated long non-coding RNAs (lncRNAs) was implicated in the tumorigenesis and progression. LncRNA TUSC7 was involved in various malignancies. However, the role of TUSC7 in human non-small-cell lung cancer (NSCLC) remains unclear. METHODS:Expression of TUSC7 was analyze...

journal_title：American journal of translational research

authors： Wang Z,Jin Y,Ren H,Ma X,Wang B,Wang Y

更新日期：2016-02-15 00:00:00

abstract：PURPOSE:This study aimed to determine whether chronic intraocular pressure (IOP) elevation induces retinal oxidative stress and alters mitochondrial morphology and function of retinal ganglion cells (RGC) and to explore the effects of AAV-SOD2 gene therapy on the RGC survival and mitochondrial dysfunction. METHODS:Chr...

journal_title：American journal of translational research

authors： Jiang W,Tang L,Zeng J,Chen B

更新日期：2016-02-15 00:00:00

abstract：:Circular RNAs (circRNAs), a class of endogenous RNAs, are characterized by covalently closed continuous loop without 5' to 3' polarity and polyadenylated tail. Recent studies indicated that circRNAs might play an important role in cancer. However, the function of circRNA in laryngeal squamous cell cancer tissues (LSCC...

journal_title：American journal of translational research

authors： Xuan L,Qu L,Zhou H,Wang P,Yu H,Wu T,Wang X,Li Q,Tian L,Liu M,Sun Y

更新日期：2016-02-15 00:00:00

abstract：:Pancreatic cancer ranks No.1 in mortality rate worldwide. This study aims to identify the novel anti-pancreatic cancer drugs. Human pancreatic carcinoma cell lines were purchased from ATCC. CPE-based screening assay was used to examine the cell viability. Patient derived tumor xenografts in SCID mice was established. ...

journal_title：American journal of translational research

authors： Wang B,Li Y,Tan F,Xiao Z

更新日期：2016-02-15 00:00:00

abstract：OBJECTIVES:In the present study, we investigate the effects of Mas oncogene-related gene (Mrg) C receptors (MrgC) on the expression and activation of spinal Gi protein, N-methyl-D-aspartate receptor subunit 2B (NR2B), and neuronal nitric oxide synthase (nNOS) in mouse model of bone cancer pain. METHODS:The number of s...

journal_title：American journal of translational research

authors： Sun Y,Zhang J,Lei Y,Lu C,Hou B,Ma Z,Gu X

更新日期：2016-02-15 00:00:00

abstract：:Thymopoiesis is essential and significant for development and maintenance of the robust and healthy immune system. The acute suppression of thymopoiesis induced by 5-Azacytidine (5-Aza) is an intractable clinical problem complicating chemotherapy. Interleukin 1 receptor antagonist (IL-1Ra) is a cytokine that competiti...

journal_title：American journal of translational research

authors： Yu H,Wu M,Wen B,Sun N,Xiang D,Zhang J,Zhu S,Weng S,Yu Y,Han W

更新日期：2016-02-15 00:00:00

abstract：:The prevention of doxorubicin (Dox) induced cardiotoxicity may be co-operative to recover future Dox treatment. The aim of this study was to explore the cardioprotective effects of oleanolic acid (OA), an antioxidant agent, on Dox induced cardiotoxicity. OA is a triterpenoid compound, which exist widely in plant kingd...

journal_title：American journal of translational research

authors： Goyal SN,Mahajan UB,Chandrayan G,Kumawat VS,Kamble S,Patil P,Agrawal YO,Patil CR,Ojha S

更新日期：2016-01-15 00:00:00

abstract：:Consumption of cruciferous vegetables is associated with a decreased risk of developing prostate cancer. Antineoplastic effects of cruciferous vegetables are attributable to bioactive indoles, most prominently, 3, 3'-diindolylmethane (DIM). In addition to effects on proliferation and apoptosis, DIM acts as an antiandr...

journal_title：American journal of translational research

authors： Hwang C,Sethi S,Heilbrun LK,Gupta NS,Chitale DA,Sakr WA,Menon M,Peabody JO,Smith DW,Sarkar FH,Heath EI

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:The cardioprotection of ischemic post-conditioning (IPO) has been well demonstrated after a short period of reperfusion. However, little is known about the long-term effects of IPO. This study aimed to investigate the long term cardioprotection of IPO in a rat myocardial ischemia/reperfusion model and to exp...

journal_title：American journal of translational research

authors： Wang G,Li X,Wang H,Wang Y,Zhang L,Zhang L,Liu B,Zhang M

更新日期：2015-12-15 00:00:00

abstract：:Acute myocardial ischemia/reperfusion (MIR) injury leads to severe arrhythmias and a high lethality. We aim to determine the effect of heat shock protein A12B (HSPA12B), a newly discovered member of the Hsp70 family, on heart injury parameters following MIR surgery. We used HSPA12B transgenic mice to determine its eff...

journal_title：American journal of translational research

authors： Sun Y,Ye L,Jiang C,Jiang J,Hong H,Qiu L

更新日期：2015-12-15 00:00:00

abstract：:Spinal cord injury (SCI) refers to the damage of spinal cord's structure and function due to a variety of causes. At present, many scholars have confirmed that apoptosis is the main method of secondary injury in spinal cord injury. In view of understanding the function of PI3K/Akt pathway on spinal cord injury, this s...

journal_title：American journal of translational research

authors： Zhang P,Zhang L,Zhu L,Chen F,Zhou S,Tian T,Zhang Y,Jiang X,Li X,Zhang C,Xu L,Huang F

更新日期：2015-11-15 00:00:00

abstract：:Coagulation proteases have been suggested to trigger a diversity of inflammatory responses in addition to their critical role in the coagulation cascade. It has been well established that the inflammatory and coagulation pathways are invariably linked. However, the mechanisms through which coagulation protease factor ...

journal_title：American journal of translational research

authors： Zuo P,Zuo Z,Wang X,Chen L,Zheng Y,Ma G,Zhou Q

更新日期：2015-11-15 00:00:00

abstract：:Alisertib (MLN8237, ALS), an Aurora kinase A (AURKA) inhibitor, exerts potent anti-tumor effects in the treatment of solid tumor and hematologic malignancies in preclinical and clinical studies. However, the fully spectrum of molecular targets of ALS and its anticancer effect in the treatment of chronic myeloid leukem...

journal_title：American journal of translational research

authors： Shu LP,Zhou ZW,Zi D,He ZX,Zhou SF

更新日期：2015-11-15 00:00:00

abstract：UNLABELLED:Oxidative stress plays an important role in doxorubicin (DOX)-induced cardiotoxicity. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor that orchestrates the antioxidant and cytoprotective responses to oxidative stress. In the present study, we tested whether tert-butylhydroquinone (tBHQ) c...

journal_title：American journal of translational research

authors： Wang LF,Su SW,Wang L,Zhang GQ,Zhang R,Niu YJ,Guo YS,Li CY,Jiang WB,Liu Y,Guo HC

更新日期：2015-10-15 00:00:00

abstract：PURPOSE:Primary intraosseous squamous cell carcinoma (PIOSCC) arising within an odontogenic keratocyst (OKC) is rare malignancy, entailing a poor prognosis for delayed diagnosis. The number of reports concerning this entity is extremely small. The aim of this study is to present the clinical and pathologic characterist...

journal_title：American journal of translational research

authors： Zhang L,Liu SL,Ye WM,Zheng J

更新日期：2015-10-15 00:00:00

abstract：:MTSS1 is a possible metastasis suppressor which has been proved to play a key role in metastasis of various tumors, yet its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. In present study, we reported detection of MTSS1 expression in ICC and explored its clinical significances. Tissue microarrays conta...

journal_title：American journal of translational research

authors： Shi W,Hasimu G,Wang Y,Li N,Chen M,Zhang H

更新日期：2015-10-15 00:00:00